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Sulbutiamine is a synthetic form of Vitamin B1 (thiamine). It is one of the oldest nootropics available, having been developed in Japan in the 1960s.
It consists of two thiamine molecules that are held together by a sulfur group. It shows a lot of promise for treating people fatigue and an abnormal lack of energy – including chronic fatigue syndrome1https://www.ncbi.nlm.nih.gov/pubmed/219821205https://europepmc.org/abstract/med/10573727 and asthenia.4https://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=4&p_RefId=533848&p_IsPs=N6[https://www.ncbi.nlm.nih.gov/pubmed/14628585 Sulbutiamine has even shown promise for improving sexual performance.7https://www.ncbi.nlm.nih.gov/pubmed/15776829
Sulbutiamine can be especially useful for individuals who are deficient in thiamine, as sulbutiamine is extremely effecting at delivering thiamine to the brain. And since thiamine is used for acetylcholine synthesis, sulbutiamine also shows promise for improving the formation of long term memories.3https://www.ncbi.nlm.nih.gov/pubmed/10996447
Sulbutiamine appears to modulate dopaminergic and glutaminergic cortical transmissions in the brain.2https://www.ncbi.nlm.nih.gov/pubmed/10996447 It also elevates acetylcholine by increasing high-affinity choline uptake3https://www.ncbi.nlm.nih.gov/pubmed/10996447, which may explain its ability to improve long-term memory.
Anecdotally, many users report sulbutiamine to be an effective mood and energy mood enhancer that can also greatly improve motivation and focus. And since thiamine is involved in acetylcholine synthesis, sulbutiamine is also great for enhancing memory.
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Sulbutiamine Dosage Information
The typical dosage for sulbutiamine is 200mg taken once or twice a day. There have been reports have tolerance from repeated use, so it may be best to use sparingly.