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Sulbutiamine is a synthetic form of Vitamin B1 (thiamine), consistig of two thiamine molecules bound together by a sulfur group. It is one of the oldest nootropics available, having been developed in Japan in the 1960s.
Sulbutiamine shows a lot of potential for raising physical energy levels, especially in people who have abnormally low energy.1https://www.ncbi.nlm.nih.gov/pubmed/219821205https://europepmc.org/abstract/med/10573727 and asthenia.4https://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=4&p_RefId=533848&p_IsPs=N6[https://www.ncbi.nlm.nih.gov/pubmed/14628585 Sulbutiamine has also shown a lot promise for improving sexual performance.7https://www.ncbi.nlm.nih.gov/pubmed/15776829
For individuals who are deficient in thiamine, supplementation of sulbutiamine can be extremely effective at restoring optimal levels of thiamine to the brain. Thiamine serves many roles in the brain, which includes being used for acetylcholine synthesis. Acetylcholine is the primary neurotransmitter in the brain responsible for learning and memory, and as such sulbutiamine supplementation also also shown promise for improving the formation of long term memories.3https://www.ncbi.nlm.nih.gov/pubmed/10996447
Interestingly, sulbutiamine appears to modulate dopaminergic and glutaminergic cortical transmissions in the brain.2https://www.ncbi.nlm.nih.gov/pubmed/10996447 It also directly elevates levels acetylcholine and increases high-affinity choline uptake3https://www.ncbi.nlm.nih.gov/pubmed/10996447, which further boosts its memory-enhancing properties, especially for long term memory.
Anecdotally, many users report sulbutiamine to be an effective mood and energy mood enhancer that can also greatly improve motivation and focus. And since thiamine is involved in acetylcholine synthesis, sulbutiamine is also great for enhancing memory.
Where to Purchase Sulbutiamine[Vendor Info]
Sulbutiamine Dosage Information
The typical dosage for sulbutiamine is 200mg taken once or twice a day. There have been reports have tolerance from repeated use, so it may be best to use sparingly.
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