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Selank is a nootropic peptide developed in Russia alongside it’s cousin Semax. It is a synthetic analogue of the tetrapeptide tuftsin3https://www.ncbi.nlm.nih.gov/pubmed/20919548 that provides anxiolytic, psychostimulatory, and antidepressant effects7https://www.ncbi.nlm.nih.gov/pubmed/186617859https://link.springer.com/article/10.1134/S1819712414020081.
It’s also been shown to cause alterations in the expression of genes involved in inflammation10https://www.sciencedirect.com/science/article/abs/pii/S016701151100086311https://www.sciencedirect.com/science/article/pii/S016158901300544012https://link.springer.com/article/10.1134/S1022795411050103. Specifically, it appears to modulate the expression of Interleukin-6 (IL-6) and regulate levels of Th1/Th2/Tred cytokines through direct and indirect mechanisms1[https://www.ncbi.nlm.nih.gov/pubmed/18577961/f]14https://europepmc.org/abstract/med/19882898.
This demonstrates immunomodulating and adaptogenic effects, and is particularly effective for people with depression and anxiety.
Due to it’s immunomodulating effects, it’s been demonstrated to have antiviral activity, and was shown to completely suppress ithe influenza virus11https://www.sciencedirect.com/science/article/pii/S01615891300544014https://europepmc.org/abstract/med/19882898.
Selank increases levels of the monoamine neurotransmitters in the different parts of the brain through various mechanisms. Specifically norepinephrine, dopamine, and serotonin were found to be significantly elevated. Serotonin concentrations were strongest in the hippocampus, norepinephrine in the hypothalamus, and dopamine in the frontal cortex and hippocampus2https://europepmc.org/abstract/med/18661785.
Selank was even shown to increase the metabolism of serotonin in the hypothalamus and brain stem3https://www.ncbi.nlm.nih.gov/pubmed/209195484https://www.ncbi.nlm.nih.gov/pubmed/19803361. And it seems to increase dopamine synthesis and turnover and modulate tyrosine hydroxylase activity.7https://www.ncbi.nlm.nih.gov/pubmed/18661785. Additionally, it appears to increase BDNF expression in the hippocampus6https://www.ncbi.nlm.nih.gov/pubmed/18841804
In regards to it’s nootropic properties, Selank improves sensory attention, learning, and restores the balance of serotoninergic and noradrenergic systems of the brain8https://link.springer.com/article/10.1007/s11055-008-0030-2. It also enhances memory storage processes, which is the primary mechanism behind its nootropic actions3https://www.ncbi.nlm.nih.gov/pubmed/20919548.
Selank’s posseses strong anxiolytic effects15https://link.springer.com/article/10.1023/A:101797951427416https://europepmc.org/abstract/med/18454096 that are quite unique and lack have the typical side-effects of other anxiolytics. The anxiolytic effects of Selank come from preventing the breakdown of enkephalin15https://link.springer.com/article/10.1023/A:101797951427417https://www.ncbi.nlm.nih.gov/pubmed/11443939, which is a naturally-occuring opioid peptide in the body. Thus Selank is a often suggested to be effective for anxiety and phonic disorders as well as generalized anxiety16https://europepmc.org/abstract/med/18454096.
Overall Selank is a very unique drug that has a fascinating pharmacological profile. It is an excellent option for reducing anxiety and depression because it is non-addictive and does not posses side-effects typical of other drugs used for similar purposes.
Where to Purchase Selank
Pharmacy-produced Russian Selank may be purchased at Cosmic Nootropic.
Selank Dosage Information
Selank is only bioavailable when taken intranasally, as it is degraded in the gut. With a 15% formulation used, a standard dose is 150-225 mcg used up three times a day for up to 14 days.