Pramiracetam is one of the most interesting racetam drugs out there, as it has very little effect on overall mood. Strictly speaking, it is one of the closest drugs that resembles the definition of a true nootropic; its primary effects are improving memory and learning, as well as providing neuroprotection.
Pramiracetam seems to exclusively works on the acetylcholine system1www.ncbi.nlm.nih.gov/pubmed/2987637, with seemingly no effect on other neurotransmitters in the brain2onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430030503.
In regards to its cholinergic properties, it appears to primarily enhance hippocampal cholinergic neuronal activity in the brain1www.ncbi.nlm.nih.gov/pubmed/29876372onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430030503, and this effect looks even stronger in the hippocampus when compared to piracetam4https://link.springer.com/article/10.2165/11319230-000000000-00000. It also seems to have a stronger demand for high-affinity choline uptake (HACH), which ultimately results in an acceleration of acetylcholine turnover1www.ncbi.nlm.nih.gov/pubmed/29876372onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430030503.
Pramiracetam has been shown to significantly improve objective memory5www.ncbi.nlm.nih.gov/pubmed/186530016www.ncbi.nlm.nih.gov/pubmed/2765166, as well as improved measures of delayed recall, spatial learning, and long-term memory7www.ncbi.nlm.nih.gov/pubmed/30886668europepmc.org/abstract/med/147387910https://www.ncbi.nlm.nih.gov/pubmed/3088666. It has also been shown to significantly improve delayed recall in young males with brain injuries9https://www.ncbi.nlm.nih.gov/pubmed/1786500, and reduce scopolamine-induced memory deficits11https://www.ncbi.nlm.nih.gov/pubmed/15374306.
Overall, pramiracetam appears to have a very strong affinity for the cholinergic system. Since it is most active in the hippocampus, the site for memory consolidation3science.sciencemag.org/content/304/5672/839, in theory you could infer that it is the most effective racetam for improving memory, but more studies are needed to know how it compares.
If you’re looking for a drug that simply improves memory and does not come with unpredictable changes in mood and behavior, pramiracetam may be a great choice.
Where to Purchase Pramiracetam
Pramiracetam may be purchased at Nootropics Depot.
I recommend Nootropics Depot because they have been around for a long time and have maintained a solid reputation. They have excellent quality control metrics: they do in-house testing as well as independent 3rd-party testing, and they have certificates of analysis available for all of their products.
The half-life of pramiracetam is about 4.5 to 6.5 hours12https://www.ncbi.nlm.nih.gov/pubmed/4008675 . The recommended dosage is 400mg to 600mg up to three times daily.
Pramiracetam has been shown to rapidly increase acetylcholine turnover. As such, it is a good idea to take it with nootropics that provide acetylcholine. I recommended sticking to the normal doses of each nootropic when using this stack.
Ex: if using alpha-gpc, start with a normal dose of 300mg even if you take it with pramiracetam.