Picamilon, the Hard-To-Find Nootropic for Anxiety Reduction


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Picamilon is a drug developed in Russia that has shown potential to treat anxiety and depression.5https://www.ncbi.nlm.nih.gov/pubmed/16845932 Picamilon is a safer alternative to it’s older brother Phenibut which is used for similar purposes. In fact, Phenibut was actually developed for use by cosmonauts, while Picamilon was developed for use by the regular citizens.

Picamilon is a fairly simple drug; it’s a synthetic combination of GABA and niacin (Vitamin B3). GABA is the primary inhibitory neurotransmitter in the brain and can reduce anxiety and improve mood.3https://www.ncbi.nlm.nih.gov/pubmed/28845494https://www.ncbi.nlm.nih.gov/pubmed/15131523 Ordinarily, GABA cannot cross the blood brain barrier when directly supplemented. However, picamilon is able to cross the blood-brain barrier quite effectively1https://www.ncbi.nlm.nih.gov/pubmed/1884802, and can directly increase levels of circulating GABA in the brain.

Unlike Phenibut, which acts as a GABA agonist, picamilon merely supplies the brain with GABA, which makes it significantly less prone to abuse and addiction. As such, picamilon provides a more subtle anxiety-reducing and mood-brightening effect. With that in mind, picamilon can be used much more frequently without any serious complications, which makes it an attractive alternative to phenibut.

Interestingly enough, picamilon is not considered a “dietary supplement” (an already arbitrary category) by the FDA. While it is not illegal or scheduled to possess or buy picamilon, it is not able to be sold as a dietary supplement, which makes it incredibly hard to find since it is not manufactured in the US.

Picamilon may provide some additional benefits beyond reducing anxiety, which include some nootropic properties. Picamilon has also been shown to increase long-term and short-term memory in rats6https://link.springer.com/article/10.1007%2FBF02446941 and provide neuroprotection.7https://www.ncbi.nlm.nih.gov/pubmed/96211808https://link.springer.com/article/10.1007%2FBF00839928#page-2 Additionally, since niacin acts as a vasodilator2https://www.ncbi.nlm.nih.gov/pubmed/17705685, picamilon widens blood vessels and significantly increases blood flow to the brain.9https://link.springer.com/article/10.1007%2FBF00841781#page-1



Where to Buy Picamilon


Pharmacy-produced picamilon is available at Cosmic Nootropic.



Picamilon Dosage Information

A standard dose of picamilon is 30mg-50mg taken up to three times a day. It is not recommended to take more than 200mg in a day. Side effects of picamilon are typically mild and include skin flushing (due to niacin), and possible dizziness/nausea.




  1. https://www.ncbi.nlm.nih.gov/pubmed/1884802
  2. https://www.ncbi.nlm.nih.gov/pubmed/17705685
  3. https://www.ncbi.nlm.nih.gov/pubmed/2884549
  4. https://www.ncbi.nlm.nih.gov/pubmed/15131523
  5. https://www.ncbi.nlm.nih.gov/pubmed/16845932
  6. https://link.springer.com/article/10.1007%2FBF02446941
  7. https://www.ncbi.nlm.nih.gov/pubmed/9621180
  8. https://link.springer.com/article/10.1007%2FBF00839928#page-2
  9. https://link.springer.com/article/10.1007%2FBF00841781#page-1