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Phenibut (aminophenylbutyric acic) is a unique nootropic drug that was developed for the treatment of anxiety, insomnia, PTSD, and depression.
Phenibut was first discovered in Russia in the 1960s at the A.I. Herzen Leningrad Pedagogical Institute under the leadership of Professor Vsevolod Perekalin. The compound underwent testing at the Institute of Experimental Medicine, USSR Academy of Medical Sciences. Interestingly, it has been included in kits for Russian Cosmonauts for decades, due to its remarkable qualities.
In some countries it is sold as a prescription, but in the US and many other countries it is considered a dietary supplement. As such, it is fully legal and available over the counter. Phenibut’s availability and affordability make it one of the most popular over the counter nootropics in the world.
However, don’t be fooled, just because it’s easy to acquire and cheap doesn’t make it weak. It is quite a powerful substance and should be used with care and precision.
How it’s Used
Phenibut is most commonly used as a prosocial mood brightener, sleep aid, and nootropic. While it’s nootopic potential is still under investigation, it does appear to have some potential in enhancing motivation and creativity.
Phenibut has many qualities that make it viable for different situations. It’s a reliable pick-me-up and can greatly improve mood and may even cause mild euphoria. It tends to significantly reduce social inhibition, and can make you feel more present and in the moment.
Interestingly, unlike other compounds of this class, it does not “dumb you down” or make you feel slow and lethargic. Quite the contrary, it is interesting to note that it can actually make you more energized and sharp-witted.
These qualities makes phenibut quite appealing because it can be thought of as a performance enhancer in this sense, and may even be useful for a variety of different activities. It can also be thought of as a as a general experience-enhancer for things like music, sex, working out, and socializing.
By in large, however, it should be noted that phenibut is most appropriate to use for social situations, especially for special events such as presentations, festivals, etc.
How it Works
Phenibut works by increasing levels of GABA in the brain.2https://www.ncbi.nlm.nih.gov/pubmed/18275958 GABA is the primary inhibitory neurotransmitter in the body, and it is responsible for regulating mood, relaxation, and sleep. Phenibut is unique is actually GABA analogue and directly binds to the GABA-B receptor site.2https://www.ncbi.nlm.nih.gov/pubmed/18275958
Phenibut is unique due to its ability to promote relaxation and improve mood without causing sedation or negatively affecting cognitive peformance.1https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3458.2001.tb00211.x As stated earlier, this is because phenibut has demonstrated both stimulatory and depressant qualities.1https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3458.2001.tb00211.x
It does trigger a moderate release of dopamine3https://www.ncbi.nlm.nih.gov/pubmed/11830761 which may explain it’s nootropic and stimulatory effects. Interestingly, phenibut has been shown to be neuroprotective as well, which may further help demonstrate true cognitive-enhancing potential 4https://www.ncbi.nlm.nih.gov/pubmed/266212445https://www.ncbi.nlm.nih.gov/pubmed/16878492.
Where to Buy Phenibut
Phenibut Dosage Information
Phenibut takes quite a long time to kick in and varies depending on the individual, dosage, and whether it was taken on an empty stomach. The comeup typically does not start until about an hour after dosing, and it may not peak until 2-4 hours, but for some people it may not peak for 6 hours or later. The half life is about 5.3 hours.2https://www.ncbi.nlm.nih.gov/pubmed/18275958
The therapeutic dose range is considered to be about 250mg-500mg.
As a good rule of thumb, I strongly suggest taking no more than about 1500mg of phenibut per week. Some people choose to take 250-500mg every few of days, others may suggest taking about 750-1500mg once a week. Generally, sticking to hard limit of 1500mg total per week is a surefire way of preventing unwanted side effects.
Care should still be taken when using phenibut; overdoses can cause neausea, vomiting, unconsciousness. People who chronically abuse phenibut at high doses may risk dependence, withdrawal, and addiction and therefore care should be exercised.6https://www.ncbi.nlm.nih.gov/pubmed/26693960 Furthermore, phenibut should never be combined with alcohol or depressants such as xanax, these effects may compound upon on another.
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