Last Updated on
Phenibut (aminophenylbutyric acic) is a drug developed in the Soviet Union in the 1960s primarily for the treatment of anxiety, insomnia, PTSD, and depression. In some countries it is sold as a prescription, and in the US it is considered a dietary supplement. Phenibut is a unique drug that possesses both nootropic and anxiolytic qualities.1https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3458.2001.tb00211.x
It it most commonly used to treat anxiety, depression, and insomnia, as is known to promote deep relaxation. Phenibut is unique among depressant drugs due to its ability to promote relaxation and improve mood without causing heavy sedation or otherwise poor cognitive functioning.1https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3458.2001.tb00211.x. As such phenibut is a very popular choice for socializing, and is a much safer alternative to alcohol.
Like many depressant drugs, phenibut works by increasing levels of GABA in the brain.2https://www.ncbi.nlm.nih.gov/pubmed/18275958 GABA is the primary inhibitory neurotransmitter in the body, and its presence can reduce anxiety and improve sleep. However, unlike other GABAergics which modulate various GABA regulatory sites (such as benzodiazipines , barbiturates, and alcohol), Phenibut is unique in that it’s actually a GABA analogue and directly binds to the GABA-B receptor site.2https://www.ncbi.nlm.nih.gov/pubmed/18275958 This simply means that Phenibut has a more direct mechanism of action (MoA) with fewer side effects and more consistency in contrast with something like xanax or alcohol.
Anecdotally, many people describe phenibut as feeling like alcohol without any cognitive impairment. For this reason, some consider it a nootropic, and while it does have nootropic-like qualities, it is not strictly a nootropic on its own right. That said, it is certainly much safer than almost any other depressant drug out there, and the lack of any significant effects on cognitive performance is impressive.
In fact phenibut is quite safe; no deaths have ever been reported. However, care should still be taken when using phenibut; overdoses can cause neausea, vomiting, unconsciousness, as well as kidney and liver damage have been reported from people who abuse the drug.
Where to Buy Phenibut
Phenibut Dosage Information
Phenibut takes quite a long time to kick in and varies depending on the individual, dosage, and whether it was taken on an empty stomach. The comeup typically does not start until about an hour after dosing, and it may not peak until 2-4 hours, but for some people it may not peak for 6 hours or later. The half life is about 5.3 hours.2https://www.ncbi.nlm.nih.gov/pubmed/18275958
When sold as a prescription, the therapeutic dose is 250mg. I would suggest taking no more than about 1500mg in one day because it becomes more recreational than therapeutic, and can increase the likelihood if side effects and complications if combined with other substances.
Overall, phenibut induces euphoria, reduces anxiety, and increases sociability, but it has potential for addiction if it is abused. I believe it is better thought of as a drug used on an acute, as-needed basis, and should not be taken daily.