Oxiracetam for Long-Term Potentiation


Last Updated on




Oxiracetam is a more potent form of aniracetam and piracetam and shares many similarities.

Oxiracetam is an excitatory nootropic drug that effects the ACh system2https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.4302804093https://www.ncbi.nlm.nih.gov/pubmed/3594455, and appears to be even more effective than Piracetam for increasing concentrations of acetylcholine in the brain4https://www.ncbi.nlm.nih.gov/pubmed/3594455.

Oxiracetam, also like Aniracetam, also appears to strongly modulate the AMPA receptor via increased glutamatergic signaling, which can cause increased brain activity, and when combined with increasing the release acetylcholine, appears to have a similar MoA to the other racetams.

What really sets oxiracetam apart, however, is its effect on the AMPA receptors. Oxiracetam, via modulation of the AMPA receptors, has been shown to cause long-term potentiation in the hippocampus5https://www.ncbi.nlm.nih.gov/pubmed/30186336https://www.ncbi.nlm.nih.gov/pubmed/2564640. Long-term potentiation is effectively a strengthening of synapses based on recent activities that were performed. The hippocampus, among many of it’s roles, is implicated in the consolidation of short-term memory into long-term memory1http://science.sciencemag.org/content/304/5672/839.

This means that if were to spend four hours studying after taking long-term potentiator like oxiracetam, that the information, in theory, would be encoded more strongly in the synapses. Furthermore this strengthening of the synaptic connections would be effect the region of the brain that is specifically involved in memory consolidation (hippocampus).

In short, oxiracetam seems like it would be one of the best nootropics for learning and memory, and it makes an excellent studying tool. Like aniracetam, oxiracetam appears to be an potent ampakine, and it shows further promise by having a stronger affinity for the ACh system and for promoting long-term potentiation in the hippocampus.  However, oxiracetam is the least studied of the first-tier of racetams, and so it’s hard to say for certain if it’s truly more effective.

Personally, I found it to be among the most consistent of the three in terms of the effects. Oxiracetam, along with a choline supplement, were some of the only nootropics I regularly used in my college days, and it is my personal recommendation.


Where to Purchase Oxiracetam


Oxiracetam Capsules | 750mg

Nootropics Depot is recognized for having some of the best quality-control measure in the industry and utilize both in-house and 3rd-party testing facilities. They also provide certificates of authenticity for all of their products.



Oxiracetam Dosage Information

The half-life is about 108 minutes7https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430020507, which would require a 2nd or 3rd dose if you want to use it all day. A standard dose is in the range of 400-800mg, which should be taken up to 3 times daily, for a total of up to 2,400mg.



Oxiracetam Stack Advice

Oxiracetam use can lead to lower levels of circulating acetylcholine, and thus should be combined with nootropics that provide acetylcholine. Use the normal recommended doses for each nootropic when using this stack.

Ex: if using alpha-gpc, start with the normal dose of 150mg, even if you take it with oxiracetam.




1. science.sciencemag.org/content/304/5672/839

2. onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430280409

3. www.ncbi.nlm.nih.gov/pubmed/3594455

4. www.ncbi.nlm.nih.gov/pubmed/3594455

5. www.ncbi.nlm.nih.gov/pubmed/3018633

6. www.ncbi.nlm.nih.gov/pubmed/2564640

7. onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430020507