Oxiracetam for Long-Term Potentiation





Oxiracetam is a more potent form of aniracetam and piracetam and shares many similarities.

Oxiracetam is an excitatory nootropic drug that effects the acetylcholine system2https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.4302804093https://www.ncbi.nlm.nih.gov/pubmed/3594455, and appears to be even more effective than Piracetam for increasing concentrations of acetylcholine in the brain4https://www.ncbi.nlm.nih.gov/pubmed/3594455.

Its primary mechanism comes from increased glutamatergic signaling via AMPA receptor modulation. This, when combined with increasing the release of acetylcholine, can cause increased brain activity and communication between hemispheres.

What really sets oxiracetam apart, however, is its effect on the AMPA receptors. Oxiracetam, via modulation of the AMPA receptors, has been shown to cause long-term potentiation in the hippocampus5https://www.ncbi.nlm.nih.gov/pubmed/30186336https://www.ncbi.nlm.nih.gov/pubmed/2564640. Long-term potentiation is effectively a strengthening of synapses based on recent activities that were performed. The hippocampus, among many of it’s roles, is implicated in the consolidation of short-term memory into long-term memory1http://science.sciencemag.org/content/304/5672/839.

This means that if were to spend four hours learning and absorbing new information after taking long-term potentiator like oxiracetam, the information, in theory, would be encoded more strongly in the synapses. Furthermore, this strengthening of the synaptic connections would effect the region of the brain that is specifically involved in memory consolidation (hippocampus).

Like aniracetam, oxiracetam appears to be an potent ampakine, and it shows further promise by having a stronger affinity for the ACh system and for promoting long-term potentiation in the hippocampus.  However, oxiracetam is the least studied of the first-tier of racetams, and so it’s hard to say for certain if it’s truly more effective.

Personally, I found it to be among the most consistent of the three in terms of the effects. Oxiracetam, along with a choline supplement, were some of the only nootropics I regularly used in my college days, and it is my personal recommendation.


Where to Purchase Oxiracetam

Buy Oxiracetam at Pure Nootropics


Oxiracetam Dosage Information

The half-life is about 108 minutes7https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430020507, which would require a 2nd or 3rd dose if you want to use it all day. A standard dose is in the range of 400-800mg, which should be taken up to 3 times daily, for a total of up to 2,400mg.


Oxiracetam Stack Advice

Oxiracetam use can lead to lower levels of circulating acetylcholine, and thus should be combined with nootropics that provide acetylcholine. Use the normal recommended doses for each nootropic when using this stack.

Ex: if using alpha-gpc, start with the normal dose of 150mg, even if you take it with oxiracetam.



1. science.sciencemag.org/content/304/5672/839

2. onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430280409

3. www.ncbi.nlm.nih.gov/pubmed/3594455

4. www.ncbi.nlm.nih.gov/pubmed/3594455

5. www.ncbi.nlm.nih.gov/pubmed/3018633

6. www.ncbi.nlm.nih.gov/pubmed/2564640

7. onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430020507



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