Nootropics for Depression


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nootropics for depression

Depressive illness devastates millions of lives. Modern psychiatric medicine often proves very ineffective in treating it, with SRRI’s being the most commonly diagnosed drug. In many cases depression is viewed as a “chemical imbalance” which is an outdated model of depression that is very reductionistic.

The reality is that depressive illness is a complex pathology with numerous symptoms and causes. In many cases the best solution is a combination of therapy and drugs, but SRRI’s are not exactly preferential to many people due to their unreliability and often severe long-term side effects.

If you are looking for a reliable and safe way of alleviating depression, this post has you covered. I will be covering some of the best substances for safely and reliable improving mood and wellbeing.


List of the Best Nootropics for Depression



Uridine is nutrient that forms the basis of nucleic acids (specifically RNA) and is produced in our own bodies. When supplemented it is able to confer additional nootropic actions that would otherwise not be possible.

Uridine is a particularly effective nootropic due to its ability to upregulate baseline dopamine levels over time, which is a promising quality that makes it highly attractive to many people. It also heals neuronal structures in the brain, leading to enhanced  improved mood and cognition function.

Buy Uridine at Nootropics Depot


Fish Oil

Fish oil is an omega-3 fatty acid that is commonly supplemented for improving brain health and mood.

Fish oil consists of EPA and DHA which primarily have been shown to significantly improve mood and mental performance, respectively. In fact, high-EPA fish oil products are one of the most popular natural mood-brighteners available today, and the evidence is quite promising.

Buy Fish Oil at Nootropics Depot


Vitamin D

Vitamin D is an dietary nutrient that is produced in our own bodies when exposed to sunlight. However, people supplement Vitamin D if they are unable to get adequate sunlight.

Vitamin D plays many essential roles in the body which includes regulating mood,  and has recently shown potential for improving mood.

Buy Vitamin D at iHerb



Tianeptine is a unique nootropic that has many beneficial properies, and is a highly effective mood-brightening agent.

The pharmacology of Tianeptine is quite unique- in the short term it causes mood elation, while in the long-term it heals the brain and reverses damage from chronic stress. It it does not have any addiction potential or major side effects when used at the appropriate dose ranges.

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Creatine is a nutrient that serves a critical role in providing energy to the body in the form of ATP. Creatine is often thought of as a bodybuilding supplement however it also shows some modest nootropic potential.

Creatine is serves an important role in maintaining mental health, supplementation can reduce lethargy and brain fog, and can be an effective way to enhance overall wellbeing and mood.

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Magnesium is an essential dietary mineral that also plays a critical role in maintaining mental health. Magnesium is fairly hard to acquire from diet alone, therefore supplementation is often necessary.

Low levels of magnesium have been linked to various problems, namely poor emotional and attentional regulation. It acts as a modulator of brain activity and can prevent over-excitability in neurons, leading to healthier and stable brain activity.

Buy Magnesium at Nootropics Depot


Panax Ginseng

Panax ginseng is an adaptogen, a class of compounds which improving wellbeing by stabilzing mood and physical health.

Compared with other adaptogens, panax ginseng shows the most promise for improving social behavior and elevating mood.

Buy Panax Ginseng at Nootropics Depot


Bacopa Monnieri

Bacopa Monnieri is an herbal nootropic that has some unique properties. It is typically supplemented to improve memory and mood, and shows potential be an effective nootropic for improving mood.

Bacopa primarily works by increasing levels of serotonin and preventing neuroinflammation.

Buy Bacopa at Nootropics Depot


Rhodiola Rosea

Rhodiola rosea is a nootropic herb of the adaptogen class that shares some similarities with panax ginseng. Like other adaptogens, it is characterized by conferring a wide range of benefits to both mental and physical health.

Rhodiola has been shown to raise energy levels and promote wellbeing. It primarily works by modestly boosting levels of dopamine and serotonin, two key neurotransmitters for regulating mood and emotion.

Buy Rhodiola Rosea at Nootropics Depot



Aniracetam is a racetamic nootropic that is commonly used to improve cognitive ability – including memory, attention, and executive function.

Despite being most known for cognitive enhancement, aniracetam also appears some modest mood-brightening qualities from increased levels of dopamine and serotonin.

Buy Aniracetam at Nootropics Depot



Phenylpiracetam is a nootropic stimulant that can enhance psychomotor activity and improve alertness.

Phenylpiracetam is able to cause noticeable mood elevation from a heightened release of dopamine. Bes tof all phenylpiracetam is nonaddictive and free of any major side effects. However, it does lose effectiveness when used frequently, and as such many people suggest taking some time off when it loses potency.

Buy Phenylpiracetam at Nootropics Depot



Semax is an unusual nootropic with some strong properties. Semax achieves the bulk of its benefits due to increasing levels of dopamine, serotonin, and BDNF in various regions of the brain.

Semax is characterized by being nonaddictive and being relatively free of any adverse effects. It can increase mental clarity quite noticeably as well and is a true nootropic in almost every sense of the word.

Buy Semax at Cosmic Nootropic



Selank is a sophisticated nootropic that was developed for similar purposes as Semax, but appears to be more effective for causing relaxation stll improving cognitive performance. In contrast with Semax, Selank is more of a mood-enhancer than a cognitive enhancer.

Selank has been shown to increase levels of serotonin, norepinephrine, and dopamine through the subtle modulation of many systems in the brain.

Buy Selank at Cosmic Nootropic



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