Nootropics for Depression


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nootropics for depression


How Nootropics Can Be Used to Alleviate Depression

Depressive illness devastates millions of lives. Modern psychiatric medicine often proves very ineffective in treating it, with SRRI’s being the most commonly diagnosed drug. In many cases depression is viewed as a “chemical imbalance” which is an outdated model of depression that is very reductionistic. The reality is that depressive illness is a complex pathology with numerous symptoms and causes. In many cases the best solution is a combination of therapy and drugs, but SRRI’s are not exactly preferential to many people due to their unreliability and often severe long-term side effects.

There are many nootropics and nootropic-like substances which have been shown to treat depression quite effectively. Due to the fact that nootropics are unregulated and unpatentable, the pharmaceutical industry is unable to monetize them for profit.  Despite the overwhelming evidence that demonstrates the effectiveness of using nootropics for depression, they are still struggling to gain mainstream acceptance.

If you are looking for a reliable and safe way of alleviating depression, this post has you covered. I hope to leave you feeling like you have other options than what big pharma would have you believe.

While I don’t intend to promote any of these substances as a cure for depression, many of them have sufficient evidence to suggest they work quite well. When combined with therapy and proper lifestyle choices (high-quality sleep, healthy diet, regular exercise, etc), nootropics can be an incredible way to further alleviate symptoms of depression.



List of the Best Nootropics for Depression



Uridine is nutrient that forms the basis of nucleic acids (specifically RNA) and is produced in our own bodies. When supplemented it is able to confer additional nootropic actions that would otherwise not be possible.

Uridine is a particularly effective nootropic due to its ability to upregulate baseline dopamine levels over time, which is a promising quality that makes it highly attractive to many people.

Learn more about Uridine



Fish Oil

Fish oil is an omega-3 fatty acid that is commonly supplemented for improving brain health and mood.

Fish oil consists of EPA and DHA which primarily have been shown to significantly reduce depression and improve cognition, respectively. In fact, high-EPA fish oil products are one of the most popular natural antidepressants available today, and the evidence is quite promising.

Learn more about Fish Oil




Vitamin D


vitamin d nootropic to use for depression


Vitamin D is an dietary nutrient that is produced in our own bodies when exposed to sunlight. However, people supplement Vitamin D if they are unable to get adequate sunlight.

Vitamin D plays many essential roles in the body which includes regulating mood,  and shown potential for alleviating depression.

Learn more about Vitamin D





Tianeptine is an antidepressant drug that has many unique nootropic actions.

The pharmacology of Tianeptine is quite unique- in the short term it brightens mood and reduces depression and anxiety, while in the long-term it heals the brain and reverses the effects of chronic stress. It is considered an atypical antidepressant because it lacks the usual mechanisms of pharmaceutical drugs, and it does not have major side effects when used at the appropriate dose ranges.

Learn more about Tianeptine





Creatine is a nutrient that serves a critical role in providing energy to the body in the form of ATP. Creatine is often thought of as a bodybuilding supplement however it also shows some modest nootropic potential.

Creatine is serves an important role in maintaining mental health and supplementation has been shown to reduce depression.

Learn more about Creatine





Magnesium is an essential dietary mineral that also plays a critical role in maintaining mental health. Magnesium is fairly hard to acquire from diet alone, therefore supplementation is often necessary.

Low levels of magnesium have been linked to various mental health problems including depression and ADHD.

Learn more about Magnesium




Panax Ginseng

panax ginseng root for depression


Panax ginseng an adaptogen, a class of compounds which can reduce stress, alleviate fatigue, and improve mood.

Compared with other adaptogens, panax ginseng shows the most promise for improving general mental health, elevating mood,  and alleviating depression.

Learn more about Panax Ginseng




Bacopa Monnieri

Bacopa Monnieri is an herbal nootropic that has some unique properties. Bacopa is typically supplemented to improve memory and mood, and shows potential be an effective nootropic for reducing depression.

Learn more about Bacopa Monnieri



Rhodiola Rosea

rhodiola rosea for depression


Rhodiola rosea is a nootropic herb of the adaptogen class that shares some similarities with panax ginseng. Like other adaptogens, it is characterized by conferring a wide range of benefits to both mental and physical health.

Rhodiola has been shown to improve mood, reduce stress and anxiety, and reduce the symptoms of depression.

Learn more about Rhodiola Rosea




Aniracetam is a racetamic nootropic that is commonly used to improve cognitive ability – including memory, attention, and executive function.

Aniracetam also appears to have anti-depressive and anxiolytic (anti-anxiety) qualities and raises levels of dopamine and serotonin.

Learn more about Aniracetam




Phenylpiracetam is a nootropic stimulant that can enhance psychomotor activity and improve alertness.

Phenylpiracetam exhibits strong moderate  antidepressive and anti-stress qualities; is nonaddictive and free of any serious side effects.

Learn more about Phenylpiracetam




Semax nootropic with antidepressant and anxiolytic effects. Semax achieves the bulk of its antidepressive benefits due to increasing levels of dopamine, serotonin, and BDNF, among other unique effects.

Semax is also characterized by being nonaddictive and being relatively free of any adverse effects.

Learn more about Semax




Selank is a nootropic that was developed for similar purposes as Semax; primarily for antidepressant and anxiolytic uses.

Selank in particular is better for mood regulation and has been shown to increase levels of serotonin, norepinephrine, and dopamine.

Learn more about Selank




Where to Purchase Nootropics

nootropics depot

*Use coupon code REDDITS at checkout and save 10% off your order!

Uridine Monophosphate Capsules

Fish Oil Capsules | 1000mg Omega-3

Creatine Monohydrate Powder

Magnesium Glycinate Capsules | 800mg

Panax Ginseng Capsules | 200mg

Synapsa Bacopa Monnieri Capsules | 320mg | Whole Plant Extract

Rhodiola Rosea Capsules | 500mg | 3% Rosavins

Aniracetam Capsules | 750mg

Phenylpiracetam Capsules | 100mg



cosmic nootropic

*Use coupon code NOOTPROF at checkout and save 10% off your order!

SELANK ® 0.15%

SEMAX® 0.1%




Tianeptine Sulfate Capsules | 25mg