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Overview of Development
Among nootropics, colouracetam is often considered a rather “exotic” substance, due to its unique, novel properties. It is among the racetam family of nootropic compounds, which are most known for their memory-enhancing properties. In contrast with the other racetams, colouracetam is a fairly new contender, but has been steadily gaining popularity over the years.
Colouracetam was originally developed in 2005 in the Japan by the pharmaceutical company Mitsubishi Tanabe Pharme. It’s primary motivation for development was for restoring brain functionality in the elderly.
Later, it was repurposed when the licensing rights were purchased by BrainCells Inc, a US-based company that specializes in biotechnology. BrainCells Inc began a 90-day phase II clinical trial to investigate its potential for treating mood disorders, however they have since discontinued any further research due to a lack of funding.
In the US, coloracetam is considered a dietary supplement, however in most countries it is only available by prescription, though it is legal to own and import.
While preliminary evidence is still in its infancy, it’s very encouring so far and more studies are urgently needed.
How it Works
Colouracetam is most commonly sought after as a cogntive enhancer and mood brightener. However, there are other reported peripherial effects such as increased visual acuity and musical appreciation, though this may be mere sensationalized hype. However, given it’s structural similary to other racetams, it would not be a stretch to expect a similar range of effects on the brain as with other racetam compounds such as aniracetam.
Colouracetam primarily works by increasing the rate of high-affinity choline uptake (HACU)1https://www.ncbi.nlm.nih.gov/pubmed/7710736, which a self-modulated pathway that regulates acetylcholine synthesis in the hippocampus. Acetylcholine is used by the brain to regulate memory, learning, and attention.
In short, this means that more acetylcholine can be released into the brain than normal, leading to potentially significantly cognitive improvements.
Interestingly, this nootropic exerts effects even after it is eliminated from the body.2 This suggests that there is a cascade of downstream benefits that persist when it is no longer bioactive. Many of these downstream effects are not currently known, but they may be able to provide long-term cognitive enhancement.
What Does the Data Say?
The amount of research available on colouracetam is mostly limited to animal studies, but initial results are encouraging.
In one animal study, rats were exposed to a potent neurotoxic that caused cell degeneration in the hippocampus, leading to strong memory deficits.2https://www.ncbi.nlm.nih.gov/pubmed/20166767 After 12 days of daily colouracetam supplementation, their memory was completely restored to full working order.3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1608703/ These memory-restoring properties were found to last up to 24 hours after supplementation, and there were no notable side-effects found.4https://www.ncbi.nlm.nih.gov/pubmed/8740080
Another rat study examined the effects of supplementation on acetylcholine content in the hippocampus, the primary region of the brain responsible for memory and learning. Supplementation was found to significantly increase the content of acetylcholine by a whopping 263%.6https://www.ncbi.nlm.nih.gov/pubmed/18461273
Two more rat studies also confirmed cognitive-restoring and memory-improving properties with minimal side effects.7https://www.ncbi.nlm.nih.gov/pubmed/87400808https://www.ncbi.nlm.nih.gov/pubmed/17467960 Furthermore, the researchers found that these effects persisted for days after the last dose, which further demonstrates that colouracetam can provide long-lasting benefits.
There has been at least one high-quality human trial on the effects of supplementing this nootropic compound. In a double-blind, randomized placebo-controlled study, patients with mood disorders and were given 80mg of colouracetam for six weeks. After the six weeks were up, patients demonstrated clinically significant improvements in their moods and overall wellbeing.5
It seems that the potential of this nootropic compound for not just cogntion but overall mood. However, human studies are lacking, and there are is insufficient data in general in general to make any strong conclusion.
There does not appear to be any serious side effects from supplementation, but caution should still be exercised. As a cogntive enhancer, this nootropic may have some serious power. When it comes to enhancing mood and wellbeing, the data is less clear. User experiences tend to vary quite a lot, which is typical of racetams as they have an unusually complex pharmacological profile.
Where to Buy Coluracetam
A standard dosage 5-20mg taken once daily. One human study used 80mg daily, but it is unknown if it is necessary to take doses in this high of a range.
5. BrainCells, Inc. Trial Results. BrainCells Inc. Announces Results from Exploratory Phase 2a Trial of BCI-540 in Depression With Anxiety: Positive Signal Observed in Difficult-to-Treat Patient Population. Evaluate Group. Evaluate, Ltd., 14 June 2010. 4 Dec. 2014.
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